Increased gene expression variability in BRCA1-associated and basal-like breast tumours.

ABSTRACT:

Purpose

Inherited variants in the cancer susceptibility genes, BRCA1 and BRCA2 account for up to 5% of breast cancers. Multiple gene expression studies have analysed gene expression patterns that maybe associated with BRCA12 pathogenic variant status; however, results from these studies lack consensus. These studies have focused on the differences in population means to identified genes associated with BRCA1/2-carriers with little consideration for gene expression variability, which is also under genetic control and is a feature of cellular function.

Methods

We measured differential gene expression variability in three of the largest familial breast cancer datasets and a 2116 breast cancer meta-cohort. Additionally, we used RNA in situ hybridisation to confirm expression var

SUBMITTER: Wiggins GAR 

PROVIDER: S-EPMC8357684 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature