Expression gradient of metalloproteinases and their inhibitors from proximal to distal segments of abdominal aortic aneurysm.

ABSTRACT: Abdominal aortic aneurysm refers to abnormal, asymmetric distension of the infrarenal aortic wall due to pathological remodelling of the extracellular matrix. The distribution of enzymes remodelling the extracellular matrix and their expression patterns in the affected tissue are largely unknown. The goal of this work was to investigate the expression profiles of 20 selected genes coding for metalloproteinases and their inhibitors in the proximal to the distal direction of the abdominal aortic aneurysm. RNA samples were purified from four lengthwise fragments of aneurysm and border tissue obtained from 29 patients. The quantities of selected mRNAs were determined by real-time PCR to reveal the expression patterns. The genes of interest encode collagenases (MMP1, MMP8, MMP13), gelatinases (

SUBMITTER: Augusciak-Duma A 

PROVIDER: S-EPMC8357691 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature