Designing electrode configuration of electroosmosis based edema treatment as a complement to hyperosmotic therapy.

ABSTRACT:

Background

Hyperosmotic therapy is a mainstay treatment for cerebral edema. Although often effective, its disadvantages include mainly acting on the normal brain region with limited effectiveness in eliminating excess fluid in the edema region. This study investigates how to configure our previously proposed novel electroosmosis based edema treatment as a complement to hyperosmotic therapy.

Methods

Three electrode configurations are designed to drive the excess fluid out of the edema region, including 2-electrode, 3-electrode, and 5-electrode designs. The focality and directionality of the induced electroosmotic flow (EOF) are then investigated using the same patient-specific head model with localized edema.

Results

The 5-electrode design shows improved EOF focality w

SUBMITTER: Wang T 

PROVIDER: S-EPMC8357759 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature