In situ motions of individual inner-hair-cell stereocilia from stapes stimulation in adult mice.

ABSTRACT: In vertebrate hearing organs, mechanical vibrations are converted to ionic currents through mechanoelectrical-transduction (MET) channels. Concerted stereocilia motion produces an ensemble MET current driving the hair-cell receptor potential. Mammalian cochleae are unique in that the tuning of sensory cells is determined by their mechanical environment and the mode of hair-bundle stimulation that their environment creates. However, little is known about the in situ intra-hair-bundle motions of stereocilia relative to one another, or to their environment. In this study, high-speed imaging allowed the stereocilium and cell-body motions of inner hair cells to be monitored in an ex vivo organ of Corti (OoC) mouse preparation. We have found that the OoC rotates about the base of the inner pilla

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8357788 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature