Defining the variety of cell types in developing and adult human kidneys by single-cell RNA sequencing.

ABSTRACT: The kidney is among the most complex organs in terms of the variety of cell types. The cellular complexity of human kidneys is not fully unraveled and this challenge is further complicated by the existence of multiple progenitor pools and differentiation pathways. Researchers disagree on the variety of renal cell types due to a lack of research providing a comprehensive picture and the challenge to translate findings between species. To find an answer to the number of human renal cell types, we discuss research that used single-cell RNA sequencing on developing and adult human kidney tissue and compares these findings to the literature of the pre-single-cell RNA sequencing era. We find that these publications show major steps towards the discovery of novel cell types and intermediate cell

SUBMITTER: Schumacher A 

PROVIDER: S-EPMC8357940 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature