Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.
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ABSTRACT:
SUBMITTER: Ofir-Birin Y
PROVIDER: S-EPMC8357946 | biostudies-literature | 2021 Aug
REPOSITORIES: biostudies-literature
Publications
Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration.
Ofir-Birin Yifat Y Ben Ami Pilo Hila H Cruz Camacho Abel A Rudik Ariel A Rivkin Anna A Revach Or-Yam OY Nir Netta N Block Tamin Tal T Abou Karam Paula P Kiper Edo E Peleg Yoav Y Nevo Reinat R Solomon Aryeh A Havkin-Solomon Tal T Rojas Alicia A Rotkopf Ron R Porat Ziv Z Avni Dror D Schwartz Eli E Zillinger Thomas T Hartmann Gunther G Di Pizio Antonella A Quashie Neils Ben NB Dikstein Rivka R Gerlic Motti M Torrecilhas Ana Claudia AC Levy Carmit C Nolte-'t Hoen Esther N M ENM Bowie Andrew G AG Regev-Rudzki Neta N
Nature communications 20210811 1
Pathogens are thought to use host molecular cues to control when to initiate life-cycle transitions, but these signals are mostly unknown, particularly for the parasitic disease malaria caused by Plasmodium falciparum. The chemokine CXCL10 is present at high levels in fatal cases of cerebral malaria patients, but is reduced in patients who survive and do not have complications. Here we show a Pf 'decision-sensing-system' controlled by CXCL10 concentration. High CXCL10 expression prompts P. falci ...[more]
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