Studying the effect of alpha-synuclein and Parkinson's disease linked mutants on inter pathway connectivities.

ABSTRACT: Parkinson's disease is a common neurodegenerative disease. The differential expression of alpha-synuclein within Lewy Bodies leads to this disease. Some missense mutations of alpha-synuclein may resultant in functional aberrations. In this study, our objective is to verify the functional adaptation due to early and late-onset mutation which can trigger or control the rate of alpha-synuclein aggregation. In this regard, we have proposed a computational model to study the difference and similarities among the Wild type alpha-synuclein and mutants i.e., A30P, A53T, G51D, E46K, and H50Q. Evolutionary sequence space analysis is also performed in this experiment. Subsequently, a comparative study has been performed between structural information and sequence space outcomes. The study shows the s

SUBMITTER: Sen S 

PROVIDER: S-EPMC8358055 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature