Actaticas A-G, Cycloartane Triterpenes From Actaea asiatica With Their Antiproliferative Activity.
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ABSTRACT:
SUBMITTER: Hu M
PROVIDER: S-EPMC8358065 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
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Actaticas A-G, Cycloartane Triterpenes From <i>Actaea asiatica</i> With Their Antiproliferative Activity.
Hu Meigeng M Zhao Dan D Xu Xudong X Ma Guoxu G Wu Haifeng H Chen Xi X
Frontiers in chemistry 20210729
Phytochemical studies on the rhizomes of <i>Actaea asiatica</i> led to the isolation of seven new cycloartane triterpenes, actaticas A-G (<b>1-7</b>). Their structures were determined by NMR, HRESIMS, and chemical analysis. All the isolates were evaluated for their antiproliferative activity against HT-29 and McF-7 cell lines. The results showed that all the compounds displayed cytotoxicity. All compounds showed significant inhibitory effects with IC<sub>50</sub> values of 9.2-26.4 μM. ...[more]
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