Radiosensitization Effect of Gold Nanoparticles in Proton Therapy.

ABSTRACT: The number of proton therapy facilities and the clinical usage of high energy proton beams for cancer treatment has substantially increased over the last decade. This is mainly due to the superior dose distribution of proton beams resulting in a reduction of side effects and a lower integral dose compared to conventional X-ray radiotherapy. More recently, the usage of metallic nanoparticles as radiosensitizers to enhance radiotherapy is receiving growing attention. While this strategy was originally intended for X-ray radiotherapy, there is currently a small number of experimental studies indicating promising results for proton therapy. However, most of these studies used low proton energies, which are less applicable to clinical practice; and very small gold nanoparticles (AuNPs). Therefo

SUBMITTER: Cunningham C 

PROVIDER: S-EPMC8358148 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature