Effect of Point Spread Function Deconvolution in Reconstruction of Brain ¹⁸F-FDG PET Images on the Diagnostic Thinking Efficacy in Alzheimer's Disease.

ABSTRACT: Purpose: This study aims to determine the effect of applying Point Spread Function (PSF) deconvolution, which is known to improve contrast and spatial resolution in brain ¹⁸F-FDG PET images, to the diagnostic thinking efficacy in Alzheimer's disease (AD). Methods: We compared Hoffman 3-D brain phantom images reconstructed with or without PSF. The effect of PSF deconvolution on AD diagnostic clinical performance was determined from digital brain ¹⁸F-FDG PET images of AD (n = 38) and healthy (n = 35) subjects compared to controls (n = 36). Performances were assessed with SPM at the group level (p < 0.001 for the voxel) and at the individual level by visual interpretation of SPM T-maps (p < 0.005 for the voxel) by the cons

SUBMITTER: Doyen M 

PROVIDER: S-EPMC8358179 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature