A Eukaryote-Wide Perspective on the Diversity and Evolution of the ARF GTPase Protein Family.

ABSTRACT: The evolution of eukaryotic cellular complexity is interwoven with the extensive diversification of many protein families. One key family is the ARF GTPases that act in eukaryote-specific processes, including membrane traffic, tubulin assembly, actin dynamics, and cilia-related functions. Unfortunately, our understanding of the evolution of this family is limited. Sampling an extensive set of available genome and transcriptome sequences, we have assembled a data set of over 2,000 manually curated ARF family genes from 114 eukaryotic species, including many deeply diverged protist lineages, and carried out comprehensive molecular phylogenetic analyses. These reconstructed as many as 16 ARF family members present in the last eukaryotic common ancestor, nearly doubling the previously inferred

SUBMITTER: Vargova R 

PROVIDER: S-EPMC8358228 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature