Antiphospholipid antibodies and neurological manifestations in acute COVID-19: A single-centre cross-sectional study.

ABSTRACT:

Background

A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.

Methods

This single-centre cross-sectional study included 106 adult patients: 30 hospitalised COVID-neurological cases, 47 non-neurological COVID-hospitalised controls, and 29 COVID-non-hospitalised controls, recruited between March and July 2020. We evaluated nine antiphospholipid antibodies: anticardiolipin antibodies [aCL] IgA, IgM, IgG; anti-beta-2 glycoprotein-1 [aβ₂GPI] IgA, IgM, IgG; anti-phosphatidylserine/prothrombin [aPS/PT] IgM, IgG; and anti-domain I β₂GPI (aD1β2GPI) IgG.

Findings

There was

SUBMITTER: Benjamin LA 

PROVIDER: S-EPMC8358233 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature