Real-world keystroke dynamics are a potentially valid biomarker for clinical disability in multiple sclerosis.

ABSTRACT:

Background

Clinical measures in multiple sclerosis (MS) face limitations that may be overcome by utilising smartphone keyboard interactions acquired continuously and remotely during regular typing.

Objective

The aim of this study was to determine the reliability and validity of keystroke dynamics to assess clinical aspects of MS.

Methods

In total, 102 MS patients and 24 controls were included in this observational study. Keyboard interactions were obtained with the Neurokeys keyboard app. Eight timing-related keystroke features were assessed for reliability with intraclass correlation coefficients (ICCs); construct validity by analysing group differences (in fatigue, gadolinium-enhancing lesions on magnetic resonance imaging (MRI), and patients vs controls); and concu

SUBMITTER: Lam KH 

PROVIDER: S-EPMC8358561 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature