Ketamine's effect on inflammation and kynurenine pathway in depression: A systematic review.

ABSTRACT:

Background

Ketamine is a novel rapid-acting antidepressant with high efficacy in treatment-resistant patients. Its exact therapeutic mechanisms of action are unclear; however, in recent years its anti-inflammatory properties and subsequent downstream effects on tryptophan (TRP) metabolism have sparked research interest.

Aim

This systematic review examined the effect of ketamine on inflammatory markers and TRP-kynurenine (KYN) pathway metabolites in patients with unipolar and bipolar depression and in animal models of depression.

Methods

MEDLINE, Embase, and PsycINFO databases were searched on October 2020 (1806 to 2020).

Results

Out of 807 initial results, nine human studies and 22 animal studies on rodents met the inclusion criteria. Rodent studies provided st

SUBMITTER: Kopra E 

PROVIDER: S-EPMC8358579 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature