Fixel-based evidence of microstructural damage in crossing pathways improves language mapping in Post-stroke aphasia.

ABSTRACT:

Background

The complex crossing-fiber characteristics in the dual-stream system have been ignored by traditional diffusion tensor models regarding disconnections in post-stroke aphasia. It is valuable to identify microstructural damage of crossing-fiber pathways and reveal accurate fiber-specific language mapping in patients with aphasia.

Methods

This cross-sectional study collected magnetic resonance imaging data from 29 participants with post-stroke aphasia in the subacute stage and from 33 age- and sex-matched healthy controls. Fixel-based analysis was performed to examine microstructural fiber density (FD) and bundle cross-section alterations of specific fiber populations in crossing-fiber regions. Group comparisons were performed, and relationships with language scores

SUBMITTER: Zhang J 

PROVIDER: S-EPMC8358698 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature