CDK4: A Novel Therapeutic Target for Extramammary Paget's Disease.

ABSTRACT:

Background

The outcome of extramammary Paget's disease (EMPD) is poor when it progresses to metastasis because of the lack of effective systemic therapies. Recently, CDK4-targeted therapy has attracted attention as a potential therapeutic target for some cancers. The aim of this study was to analyze the impact of CDK4 expression on the survival of patients with EMPD.

Methods

We retrospectively reviewed 110 patients with EMPD. We conducted immunohistochemical analysis of CDK4 and cyclin D1 expression, and assessed the association between their expression and survival.

Results

Most EMPD lesions (108/110, 98.2%) were positive for CDK4 staining and there was a positive correlation between CDK4 expression and cyclin D1 expression (r = 0.54, p < 0.001). Tumor thickne

SUBMITTER: Hashimoto H 

PROVIDER: S-EPMC8358779 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature