Polygenic Risk Scores Derived From Varying Definitions of Depression and Risk of Depression.

ABSTRACT:

Importance

Genetic studies with broad definitions of depression may not capture genetic risk specific to major depressive disorder (MDD), raising questions about how depression should be operationalized in future genetic studies.

Objective

To use a large, well-phenotyped single study of MDD to investigate how different definitions of depression used in genetic studies are associated with estimation of MDD and phenotypes of MDD, using polygenic risk scores (PRSs).

Design, setting, and participants

In this case-control polygenic risk score analysis, patients meeting diagnostic criteria for a diagnosis of MDD were drawn from the Australian Genetics of Depression Study, a cross-sectional, population-based study of depression, and controls and patients with self-reported d

SUBMITTER: Mitchell BL 

PROVIDER: S-EPMC8358814 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature