Excess dietary fructose does not alter gut microbiota or permeability in humans: A pilot randomized controlled study.

ABSTRACT:

Introduction

Non-alcoholic fatty liver disease (NAFLD) is an increasing cause of chronic liver disease that accompanies obesity and the metabolic syndrome. Excess fructose consumption can initiate or exacerbate NAFLD in part due to a consequence of impaired hepatic fructose metabolism. Preclinical data emphasized that fructose-induced altered gut microbiome, increased gut permeability, and endotoxemia play an important role in NAFLD, but human studies are sparse. The present study aimed to determine if two weeks of excess fructose consumption significantly alters gut microbiota or permeability in humans.

Methods

We performed a pilot double-blind, cross-over, metabolic unit study in 10 subjects with obesity (body mass index [BMI] 30-40 mg/kg/m²). Each arm provided

SUBMITTER: Aleman JO 

PROVIDER: S-EPMC8358846 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature