The circulatory small non-coding RNA landscape in community-acquired pneumonia on intensive care unit admission.

ABSTRACT: Community-acquired pneumonia (CAP) is a major cause of sepsis. Despite several clinical trials targeting components of the inflammatory response, no specific treatment other than antimicrobial therapy has been approved. This argued for a deeper understanding of sepsis immunopathology, in particular factors that can modulate the host response. Small non-coding RNA, for example, micro (mi)RNA, have been established as important modifiers of cellular phenotypes. Notably, miRNAs are not exclusive to the intracellular milieu but have also been detected extracellular in the circulation with functional consequences. Here, we sought to determine shifts in circulatory small RNA levels of critically ill patients with CAP-associated sepsis and to determine the influence of clinical severity and causa

SUBMITTER: Khan HN 

PROVIDER: S-EPMC8358855 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature