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The human amniotic fluid stem cell secretome triggers intracellular Ca²⁺ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.

ABSTRACT: Second trimester foetal human amniotic fluid-derived stem cells (hAFS) have been shown to possess remarkable cardioprotective paracrine potential in different preclinical models of myocardial injury and drug-induced cardiotoxicity. The hAFS secretome, namely the total soluble factors released by cells in their conditioned medium (hAFS-CM), can also strongly sustain in vivo angiogenesis in a murine model of acute myocardial infarction (MI) and stimulates human endothelial colony-forming cells (ECFCs), the only truly recognized endothelial progenitor, to form capillary-like structures in vitro. Preliminary work demonstrated that the hypoxic hAFS secretome (hAFS-CM^Hypo ) triggers intracellular Ca²⁺ oscillations in human ECFCs, but the underlying mechanisms and the downst

SUBMITTER: Balducci V

PROVIDER: S-EPMC8358861 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature

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The human amniotic fluid stem cell secretome triggers intracellular Ca²⁺ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

The human amniotic fluid stem cell secretome triggers intracellular Ca2+ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.

OmicsDI is part of the ELIXIR infrastructure

Tweets

The human amniotic fluid stem cell secretome triggers intracellular Ca²⁺ oscillations, NF-κB nuclear translocation and tube formation in human endothelial colony-forming cells.