Interplay between SARS-CoV-2-derived miRNAs, immune system, vitamin D pathway and respiratory system.

ABSTRACT: The new coronavirus pandemic started in China in 2019. The intensity of the disease can range from mild to severe, leading to death in many cases. Despite extensive research in this area, the exact molecular nature of virus is not fully recognized; however, according to pieces of evidence, one of the mechanisms of virus pathogenesis is through the function of viral miRNAs. So, we hypothesized that SARS-CoV-2 pathogenesis may be due to targeting important genes in the host with its miRNAs, which involved in the respiratory system, immune pathways and vitamin D pathways, thus possibly contributing to disease progression and virus survival. Potential miRNA precursors and mature miRNA were predicted and confirmed based on the virus genome. The next step was to predict and identify their target

SUBMITTER: Karimi E 

PROVIDER: S-EPMC8358877 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature