Histone deacetylase 9 deficiency exaggerates uterine M2 macrophage polarization.

ABSTRACT: The maternal-foetal interface is an immune-privileged site where the semi-allogeneic embryo is protected from attacks by the maternal immune system. Uterine macrophages are key players in establishing and maintaining pregnancy, and the dysregulation of the M1-M2 subpopulation balance causes abortion. We separated two distinct mouse uterine macrophage subpopulations during early pregnancy, CD45⁺ F4/80⁺ CD206^- M1-like (M1) and CD45⁺ F4/80⁺ CD206⁺ M2-like (M2) cells. The M1 preponderance was significantly exaggerated at 6 hours after lipopolysaccharide (LPS) treatment, and adoptive transfer of M2 macrophages partially rescued LPS-induced abortion. RNA sequencing analysis of mouse uterine M2 versus M1 revealed 1837 differentiall

SUBMITTER: Liu Y 

PROVIDER: S-EPMC8358884 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature