Microvesicles carrying LRP5 induce macrophage polarization to an anti-inflammatory phenotype.

ABSTRACT: Microvesicles (MV) contribute to cell-to-cell communication through their transported proteins and nucleic acids. MV, released into the extracellular space, exert paracrine regulation by modulating cellular responses after interaction with near and far target cells. MV are released at high concentrations by activated inflammatory cells. Different subtypes of human macrophages have been characterized based on surface epitopes being CD16⁺ macrophages associated with anti-inflammatory phenotypes. We have previously shown that low-density lipoprotein receptor-related protein 5 (LRP5), a member of the LDLR family that participates in lipid homeostasis, is expressed in macrophage CD16⁺ with repair and survival functions. The goal of our study was to characterize the cargo a

SUBMITTER: Luquero A 

PROVIDER: S-EPMC8358886 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature