The Role of Formyl Peptide Receptor 1 in Uterine Contraction During Parturition.

ABSTRACT: Parturition involves the transformation of the quiescent myometrium into a highly excitable and contractile state, a process that is driven by changes in myometrial gene expression. This study aimed to identify myometrial transcriptomic signatures and potential novel hub genes in parturition, which have great significance for understanding the underlying mechanisms of successful parturition and treating labor-associated pathologies such as preterm birth. In our study, comparative transcriptome analysis was carried out on human myometrial tissues collected from women undergoing caesarean section at term in the presence (TL = 8) and absence of labor (TNL = 8). A total of 582 differentially expressed genes (DEGs) between TL and TNL tissues were identified. Gene ontology (GO), Kyoto encycloped

SUBMITTER: Chen C 

PROVIDER: S-EPMC8358927 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature