Seminal Plasma Lipidomics Profiling to Identify Signatures of Kallmann Syndrome.

ABSTRACT:

Background

Kallmann syndrome (KS) is a rare developmental disorder. Our previous metabolomics work showed substantial changes in linoleic acid and glycerophospholipid metabolism in KS. Here, we performed targeted lipidomics to further identify the differential lipid species in KS.

Methods

Twenty-one patients with KS (treatment group) and twenty-two age-matched healthy controls (HC, control group) were enrolled. Seminal plasma samples and medical records were collected. Targeted lipidomics analysis of these samples was performed using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS).

Results

Lipidomics profiling of patients with KS and the HCs showed clear separation in the orthogonal projections to latent structures-dis

SUBMITTER: Li X 

PROVIDER: S-EPMC8358976 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature