Extinction and discrimination in a Bayesian model of context fear conditioning (BaconX).

ABSTRACT: The extinction of contextual fear is commonly an essential requirement for successful exposure therapy for fear disorders. However, experimental work on extinction of contextual fear is limited, and there little or no directly relevant theoretical work. Here, we extend BACON, a neurocomputational model of context fear conditioning that provides plausible explanations for a number of aspects of context fear conditioning, to deal with extinction (calling the model BaconX). In this model, contextual representations are formed in the hippocampus and association of fear to them occurs in the amygdala. Representation creation, conditionability, and development of between-session extinction are controlled by degree of confidence (assessed by the Bayesian weight of evidence) that an active context

SUBMITTER: Krasne FB 

PROVIDER: S-EPMC8359206 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature