Identification and integrated analysis of differentially expressed long non-coding RNAs associated with periodontitis in humans.

ABSTRACT:

Background and objective

Long non-coding RNAs (lncRNAs) can act as competing endogenous RNAs (ceRNAs) to compete for micro-RNAs (miRNAs) in regulation of downstream genes, various biological functions and diseases. Yet, the expression and regulation of lncRNAs in periodontitis are not fully understood. The objective of the study was to identify potential genes (lncRNA, messenger RNA [mRNA] and miRNA) involved in periodontitis, construct lncRNA-miRNA-mRNA ceRNA networks, explore gene functions and validate gene expressions.

Material and methods

The data sets for the lncRNA, mRNA and miRNA expression profiles in gingival samples from periodontally healthy subjects and chronic periodontitis patients were obtained from the Gene Expression Omnibus. The differentially expressed ln

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8359208 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature