Longitudinal Changes in Neuromelanin MRI Signal in Parkinson's Disease: A Progression Marker.

ABSTRACT:

Background

Development of reliable and accurate imaging biomarkers of dopaminergic cell neurodegeneration is necessary to facilitate therapeutic drug trials in Parkinson's disease (PD). Neuromelanin-sensitive MRI techniques have been effective in detecting neurodegeneration in the substantia nigra pars compacta (SNpc). The objective of the current study was to investigate longitudinal neuromelanin signal changes in the SNpc in PD patients.

Methods

In this prospective, longitudinal, observational case-control study, we included 140 PD patients and 64 healthy volunteers divided into 2 cohorts. Cohort I included 99 early PD patients (disease duration, 1.5 ± 1.0 years) and 41 healthy volunteers analyzed at baseline (V1), where 79 PD patients and 32 healthy volunteers were rescan

SUBMITTER: Gaurav R 

PROVIDER: S-EPMC8359265 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature