Population pharmacokinetics of clofarabine for allogeneic hematopoietic cell transplantation in paediatric patients.

ABSTRACT:

Aims

Clofarabine has recently been evaluated as part of the conditioning regimen for allogeneic hematopoietic stem cell transplantation (HCT) in children. Pharmacokinetic (PK) exposure of different agents commonly used in conditioning regimens is strongly related to HCT outcome. Consequently, the PK of clofarabine may be important for outcome. This report describes the population PK of clofarabine in paediatric patients and one adult.

Methods

From 80 paediatric (0.5-18 years) and 1 adult patient (37 years), 805 plasma concentrations were included in pharmacokinetic analyses using nonlinear mixed effects modelling.

Results

A two-compartment model adequately described the PK of clofarabine. Body weight and estimated glomerular filtration rate (eGFR) were included as cov

SUBMITTER: Nijstad AL 

PROVIDER: S-EPMC8359279 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature