Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part III: Sheep and goat.

ABSTRACT: This report is the third in a series of studies that aimed to compile physiological parameters related to develop physiologically based pharmacokinetic (PBPK) models for drugs and environmental chemicals in food-producing animals including swine and cattle (Part I), chickens and turkeys (Part II), and finally sheep and goats (the focus of this manuscript). Literature searches were conducted in multiple databases (PubMed, Google Scholar, ScienceDirect, and ProQuest), with data on relevant parameters including body weight, relative organ weight (% of body weight), cardiac output, relative organ blood flow (% of cardiac output), residual blood volume (% of organ weight), and hematocrit reviewed and statistically summarized. The mean and standard deviation of each parameter are presented in ta

SUBMITTER: Li M 

PROVIDER: S-EPMC8359294 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature