Genome-wide association study followed by trans-ancestry meta-analysis identify 17 new risk loci for schizophrenia.

ABSTRACT:

Background

Over 200 schizophrenia risk loci have been identified by genome-wide association studies (GWASs). However, the majority of risk loci were identified in populations of European ancestry (EUR), potentially missing important biological insights. It is important to perform 5 GWASs in non-European populations.

Methods

To identify novel schizophrenia risk loci, we conducted a GWAS in Han Chinese population (3493 cases and 4709 controls). We then performed a large-scale meta-analysis (a total of 143,438 subjects) through combining our results with previous GWASs conducted in EAS and EUR. In addition, we also carried out comprehensive post-GWAS analysis, including heritability partitioning, enrichment of schizophrenia associations in tissues and cell types, trancscriptome

SUBMITTER: Liu J 

PROVIDER: S-EPMC8359304 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature