Constructing a representative in-silico population for paediatric simulations: Application to HIV-positive African children.

ABSTRACT:

Aims

Simulations are an essential tool for investigating scenarios in pharmacokinetics-pharmacodynamics. The models used during simulation often include the effect of highly correlated covariates such as weight, height and sex, and for children also age, which complicates the construction of an in silico population. For this reason, a suitable and representative patient population is crucial for the simulations to produce meaningful results. For simulation in paediatric patients, international growth charts from the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC) provide a reference, but these may not always be representative for specific populations, such as malnourished children with HIV or acutely unwell children.

Methods

We presen

SUBMITTER: Wasmann RE 

PROVIDER: S-EPMC8359354 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature