Topical corticosteroids normalize both skin and systemic inflammatory markers in infant atopic dermatitis.

ABSTRACT:

Background

Atopic dermatitis (AD) is the most common inflammatory skin disease. It is highly heterogeneous in clinical presentation, treatment response, disease trajectory and associated atopic comorbidities. Immune biomarkers are dysregulated in skin and peripheral blood.

Aims

We used noninvasive skin and peripheral biomarkers to observe the effects of real-world topical corticosteroid (TCS) treatment in infants with AD, by measuring skin and blood biomarkers before and after therapy.

Methods

Seventy-four treatment-naïve infants with AD underwent 6 weeks of TCS treatment. Stratum corneum (SC) and plasma blood biomarkers as well as SC natural moisturizing factor (NMF) were measured before and after TCS therapy. Immune markers included innate, T helper (Th)1 and Th2 im

SUBMITTER: McAleer MA 

PROVIDER: S-EPMC8359435 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature