Prediction of biological age and all-cause mortality by 12-lead electrocardiogram in patients without structural heart disease.

ABSTRACT:

Background

There is a well-established relationship between 12-lead electrocardiogram (ECG) and age and mortality. Furthermore, there is increasing evidence that ECG can be used to predict biological age. However, the utility of biological age from ECG for predicting mortality remains unclear.

Methods

This was a single-center cohort study from a cardiology specialized hospital. A total of 19,170 patients registered in this study from February 2010 to March 2018. ECG was analyzed in a final 12,837 patients after excluding those with structural heart disease or with pacing beats, atrial or ventricular tachyarrhythmia, or an indeterminate axis (R axis > 180°) on index ECG. The models for biological age were developed by principal component analysis (BA) and the Klemera and Doub

SUBMITTER: Hirota N 

PROVIDER: S-EPMC8359578 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature