Urine metabolites for the identification of Onchocerca volvulus infections in patients from Cameroon.

ABSTRACT:

Background

The tropical disease onchocerciasis (river blindness), caused by Onchocerca volvulus filarial nematodes, is targeted for elimination by mass treatment with nematocidal and antimicrobial drugs. Diagnosis of O. volvulus infections is based on counts of skin-borne microfilariae, but additional diagnostic tools, e.g. worm- or host-derived small RNAs, proteins or metabolites, are required for high-throughput screening. N-acetyltyramine-O,β-glucuronide (NATOG) was suggested as a biomarker for onchocerciasis but its viability as diagnostic tool has been challenged.

Methods

We performed a screening program of urine samples from individuals from Cameroon infected with O. volvulus, Loa loa, Mansonella perstans or a combination thereof. Urine metabolites were measured by liq

SUBMITTER: Wewer V 

PROVIDER: S-EPMC8359580 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature