Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects.

ABSTRACT:

Aims

This study aims to develop and verify a physiologically based pharmacokinetic (PBPK) population model for the Chinese geriatric population in Simcyp.

Methods

Firstly, physiological information for the Chinese geriatric population was collected and later employed to develop the Chinese geriatric population model by recalibration of corresponding physiological parameters in the Chinese adult population model available in Simcyp (i.e., Chinese healthy volunteer model). Secondly, drug-dependent parameters were collected for six drugs with different elimination pathways (i.e., metabolized by CYP1A2, CYP3A4 or renal excretion). The drug models were then developed and verified by clinical data from Chinese adults, Caucasian adults and Caucasian elderly subjects to ensure that

SUBMITTER: Cui C 

PROVIDER: S-EPMC8359847 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature