Developmental onset of enduring long-term potentiation in mouse hippocampus.

ABSTRACT: Analysis of long-term potentiation (LTP) provides a powerful window into cellular mechanisms of learning and memory. Prior work shows late LTP (L-LTP), lasting >3 hr, occurs abruptly at postnatal day 12 (P12) in the stratum radiatum of rat hippocampal area CA1. The goal here was to determine the developmental profile of synaptic plasticity leading to L-LTP in the mouse hippocampus. Two mouse strains and two mutations known to affect synaptic plasticity were chosen: C57BL/6J and Fmr1^-/y on the C57BL/6J background, and 129SVE and Hevin^-/- (Sparcl1^-/- ) on the 129SVE background. Like rats, hippocampal slices from all of the mice showed test pulse-induced depression early during development that was gradually resolved with maturation by 5 weeks. All the mouse s

SUBMITTER: Ostrovskaya OI 

PROVIDER: S-EPMC8359899 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature