Application of the ATN classification scheme in a population without dementia: Findings from the EPAD cohort.

ABSTRACT:

Background

We classified non-demented European Prevention of Alzheimer's Dementia (EPAD) participants through the amyloid/tau/neurodegeneration (ATN) scheme and assessed their neuropsychological and imaging profiles.

Materials and methods

From 1500 EPAD participants, 312 were excluded. Cerebrospinal fluid cut-offs of 1000 pg/mL for amyloid beta (Aß)1-42 and 27 pg/mL for p-tau181 were validated using Gaussian mixture models. Given strong correlation of p-tau and t-tau (R²  = 0.98, P < 0.001), neurodegeneration was defined by age-adjusted hippocampal volume. Multinomial regressions were used to test whether neuropsychological tests and regional brain volumes could distinguish ATN stages.

Results

Age was 65 ± 7 years, with 58% females and 38% apolipoprotein E

SUBMITTER: Ingala S 

PROVIDER: S-EPMC8359976 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature