Refitting the Model for End-Stage Liver Disease for the Eurotransplant Region.

ABSTRACT:

Background and aims

The United Network for Organ Sharing's Model for End-Stage Liver Disease (UNOS-MELD) score is the basis of liver allocation in the Eurotransplant region. It was constructed 20 years ago in a small US cohort and has remained unchanged ever since. The best boundaries and coefficients were never calculated for any region outside the United States. Therefore, this study refits the MELD (reMELD) for the Eurotransplant region.

Approach and results

All adult patients listed for a first liver transplantation between January 1, 2007, and December 31, 2018, were included. Data were randomly split in a training set (70%) and a validation set (30%). In the training data, generalized additive models with splines were plotted for each MELD parameter. The lower and uppe

SUBMITTER: Goudsmit BFJ 

PROVIDER: S-EPMC8359978 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature