Animal experimental research assessing urogynecologic surgical mesh implants: Outcome measures describing the host response, a systematic review and meta-analysis.

ABSTRACT:

Aim

Before the introduction of new biomaterials for prolapse surgery, animal studies on the host response are required. Unfortunately, large variation in study design hampers obtaining an overview of the safety and efficacy, and translation to clinical practice. Our aim is to systematically review the literature on all outcome measures describing the host response in animal studies assessing the biocompatibility of urogynecologic surgical mesh implants for prolapse surgery. Furthermore, by meta-analysis, we aim to assess the effect of implantation and compare this to control animals receiving sham surgery or native tissue repair.

Methods

We performed a systematic search from inception to August 2020. Since this is an explorative study we included original, controlled, and no

SUBMITTER: Verhorstert KWJ 

PROVIDER: S-EPMC8359983 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature