In vivo confocal microscopy study of corneal nerve alterations in children and youths with Type 1 diabetes.

ABSTRACT:

Objective

To determine whether children and youths with Type 1 diabetes (T1D) have early alterations of the corneal subbasal nerve plexus detectable with in vivo confocal microscopy (IVCM) and to investigate the role of longitudinally measured major risk factors for diabetes complications associated with these alterations.

Methods

One hundred and fifty children and youths with T1D and 51 age-matched controls were enrolled and underwent IVCM. Corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD), corneal fiber total branch density (CTBD), and corneal fiber fractal dimension (CNFrD) were measured. Risk factors for diabetes complications (blood pressure, BMI, HbA1c, lipoproteins, urinary albumin-creatinine ratio) were recorde

SUBMITTER: Cozzini T 

PROVIDER: S-EPMC8360056 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature