PAD4 takes charge during neutrophil activation: Impact of PAD4 mediated NET formation on immune-mediated disease.

ABSTRACT:

Background

Peptidyl arginine deiminase 4 (PAD4) is an enzyme that converts arginine into citrulline. PAD4 is expressed in neutrophils that, when activated, can drive the formation of neutrophil extracellular traps (NETs). Uncontrolled activation of PAD4 and subsequent citrullination of proteins is increasingly recognized as a driver of (auto)immune diseases. Currently, our understanding of PAD4 structure-function relationships and activity control in vivo is incomplete.

Aims

To provide the current state-of-the-art on PAD4 structure-activity relationships and involvement of PAD4 in autoimmune disorders as well as in thrombo-inflammatory disease.

Materials & methods

Literature review and molecular modelling Results: In this review, we used molecular modelling to generat

SUBMITTER: Liu X 

PROVIDER: S-EPMC8360066 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature