Influence of a novel scaffold composed of polyurethane, hydroxyapatite, and decellularized bone particles on the healing of fourth metacarpal defects in mares.

ABSTRACT:

Objective

To determine the effect of a novel scaffold, designed for use in bone regeneration, on healing of splint bone segmental defects in mares.

Study design

In vivo experimental study.

Sample population

Five adult mares (4-10 years old; mean weight, 437.7 kg ± 29 kg).

Methods

Bilateral 2-cm full-thickness defects were created in the fourth metacarpal bones (MCIV) of each horse. Each defect was randomly assigned to either a novel scaffold treatment (n = 5) or an untreated control (n = 5). The scaffold was composed of polyurethane, hydroxyapatite, and decellularized bone particles. Bone healing was assessed for a period of 60 days by thermography, ultrasonography, radiography, and computed tomography (CT). Biopsies of each defect were performed 60 days after

SUBMITTER: Grzeskowiak RM 

PROVIDER: S-EPMC8360067 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature