Increased day-to-day fluctuations in exhaled breath profiles after a rhinovirus challenge in asthma.

ABSTRACT:

Background

Early detection/prediction of flare-ups in asthma, commonly triggered by viruses, would enable timely treatment. Previous studies on exhaled breath analysis by electronic nose (eNose) technology could discriminate between stable and unstable episodes of asthma, using single/few time-points. To investigate its monitoring properties during these episodes, we examined day-to-day fluctuations in exhaled breath profiles, before and after a rhinovirus-16 (RV16) challenge, in healthy and asthmatic adults.

Methods

In this proof-of-concept study, 12 atopic asthmatic and 12 non-atopic healthy adults were prospectively followed thrice weekly, 60 days before, and 30 days after a RV16 challenge. Exhaled breath profiles were detected using an eNose, consisting of 7 different se

SUBMITTER: Lammers A 

PROVIDER: S-EPMC8360186 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature