A bi-centric experience of extracorporeal carbon dioxide removal (ECCO₂ R) for acute hypercapnic respiratory failure following allogeneic hematopoietic stem cell transplantation.

ABSTRACT: Acute respiratory failure (ARF) is the main reason for ICU admission following allogeneic hematopoietic stem cell transplantation (HSCT). Extracorporeal CO₂ removal (ECCO₂ R) can be used as an adjunct to mechanical ventilation in patients with severe hypercapnia but has not been assessed in HSCT recipients. Retrospective analysis of all allogeneic HSCT recipients ≥18 years treated with ECCO₂ R at two HSCT centers. 11 patients (m:f = 4:7, median age: 45 [IQR: 32-58] years) were analyzed. Acute leukemia was the underlying hematologic malignancy in all patients. The time from HSCT to ICU admission was 37 [8-79] months, and 9/11 (82%) suffered from chronic graft-versus-host disease (GVHD) with lung involvement. Pneumonia was the most frequent reason for ventila

SUBMITTER: Wohlfarth P 

PROVIDER: S-EPMC8360202 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature