Perceived psychological stress and risk of herpes zoster: a nationwide population-based cohort study.

ABSTRACT:

Background

Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial.

Objectives

To examine the association between perceived psychological stress and risk of HZ.

Methods

In a linked registry-based cohort study, we followed 77 310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from 1 May 2010 until HZ diagnosis, death, emigration or 1 July 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen's Perceived Stress Scale (PSS) score (range 0-40) using Cox regression with age as the timescale, adjusted for sex, immunosuppressive and selected chronic conditions, immunosuppressive drugs, and sociodemographic, l

SUBMITTER: Schmidt SAJ 

PROVIDER: S-EPMC8360205 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature