Major histocompatibility complex class II DR and DQ evolution and variation in wild capuchin monkey species (Cebinae).

ABSTRACT: The major histocompatibility complex (MHC) is an important gene complex contributing to adaptive immunity. Studies of platyrrhine MHC have focused on identifying experimental models of immune system function in the equivalent Human Leukocyte Antigen (HLA). These genes have thus been explored primarily in captive platyrrhine individuals from research colonies. However, investigations of standing MHC variation and evolution in wild populations are essential to understanding its role in immunity, sociality and ecology. Capuchins are a promising model group exhibiting the greatest habitat diversity, widest diet breadth and arguably the most social complexity among platyrrhines, together likely resulting in varied immunological challenges. We use high-throughput sequencing to characterize polym

SUBMITTER: Buckner JC 

PROVIDER: S-EPMC8360539 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature