Effects of alcohol on skeletal muscle contractile performance in male and female mice.

ABSTRACT:

Background

Acute and chronic alcohol use can cause skeletal muscle myopathy in concert with impairments in skeletal muscle strength, function and fatigue resistance. However, the fundamental contractile deficits induced in the presence of alcohol versus those observed in the recovery period following the clearance of alcohol have not yet been characterized nor is it known whether sex influences these outcomes.

Methods

Male and female mice received an intraperitoneal injection of either saline (Control) or ethanol (EtOH; 5g/kg body weight). Muscle force, fatigue, fatigue recovery and twitch characteristics of the posterior crural muscle complex were measured in situ 1 hour and 24 hours post alcohol.

Results

In the presence of alcohol (1-hour post treatment) absolute an

SUBMITTER: Laudato JA 

PROVIDER: S-EPMC8360553 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature