Circadian rhythm shows potential for mRNA efficiency and self-organized division of labor in multinucleate cells.

ABSTRACT: Multinucleate cells occur in every biosphere and across the kingdoms of life, including in the human body as muscle cells and bone-forming cells. Data from filamentous fungi suggest that, even when bathed in a common cytoplasm, nuclei are capable of autonomous behaviors, including division. How does this potential for autonomy affect the organization of cellular processes between nuclei? Here we analyze a simplified model of circadian rhythm, a form of cellular oscillator, in a mathematical model of the filamentous fungus Neurospora crassa. Our results highlight a potential role played by mRNA-protein phase separation to keep mRNAs close to the nuclei from which they originate, while allowing proteins to diffuse freely between nuclei. Our modeling shows that syncytism allows for extreme mR

SUBMITTER: Zinn-Brooks L 

PROVIDER: S-EPMC8360590 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature