Adipocyte NR1D1 dictates adipose tissue expansion during obesity.

ABSTRACT: The circadian clock component NR1D1 (REVERBα) is considered a dominant regulator of lipid metabolism, with global Nr1d1 deletion driving dysregulation of white adipose tissue (WAT) lipogenesis and obesity. However, a similar phenotype is not observed under adipocyte-selective deletion (Nr1d1^Flox2-6:Adipoq^Cre), and transcriptional profiling demonstrates that, under basal conditions, direct targets of NR1D1 regulation are limited, and include the circadian clock and collagen dynamics. Under high-fat diet (HFD) feeding, Nr1d1^Flox2-6:Adipoq^Cre mice do manifest profound obesity, yet without the accompanying WAT inflammation and fibrosis exhibited by controls. Integration of the WAT NR1D1 cistrome with differential gene expression

SUBMITTER: Hunter AL 

PROVIDER: S-EPMC8360653 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature